Mr. Muiris O'Connor:

Work is beginning and is under way on setting that up and refreshing it. It is hard to put a timeframe on it. There will be an evidence synthesis, a review of international practice and a review of relevant clinical trials from the intervening years to see if further indications can be added. I expect the review will take six to eight months to complete, so by the middle of next year we will have that review refreshed.