Mr. Muiris O'Connor:

I will ask Mr. Flanagan to come in on the reimbursement arrangements. The other two questions seem to be the different sides of benefit-risk, namely, whether we are allowing sufficient access where it is beneficial and whether we are managing the risk of it leaking beyond the programme as intended. I will bring in my own colleague on that and perhaps the HPRA will want to say something about it. I ask Mr. Flanagan to start on the reimbursement aspects.