Mr. Peter Murphy:

For example, there is an increased risk of polytherapy with valproate in pregnancy. From what we can see, this was first included in UK data sheets in 2002 but not in Ireland until 2008. From 2001, in the UK it was recommended that Epilim be used in women of childbearing age only in severe cases or in those resistant to other treatment but a similar recommendation was not in place in Ireland until 2012. There were a number of other discrepancies. Historically, the information has been available in the data sheets but ten or 15 years ago, that information was minimal. It has since expanded over the years. The question is whether it has always reflected everything about a drug that has been known and accepted.