Adult stem cells are more flexible than was believed but they are still multipotent. In other words, they try to go down the stream that one wishes them to go down. If they are myoblasts in the heart, they want to become heart cells. Similarly, if they are hepatocytes in the liver, they want to become liver cells. I witnessed terrific work where such cells could be transmitted down the portal vein into the pancreas of a diabetes patient and they began to produce insulin. This could not have happened five years ago but progress in ongoing in this field. It is important that it should not be looked on as too simple because it is not. More progress will be reported in ten years.