Dr. Colm Henry:

I will take that question first and then ask Professor Cormican or Dr. Jessop to comment. All the vaccines available are safe and effective. The recent reframing of the NIAC advice has indicated that we should use one in a particular age group and mRNA vaccines in another age group. The vaccines we are using have an emerging, strong efficacy record from clinical trials and are very effective in real world evidence, as is emerging from those countries further along in their vaccination programmes. The evidence coming through from real-life experience is that they are delivering benefits, more than we expected even from the evidence in phase 3 trials, in preventing serious illness. Does Dr. Jessop want to comment on the country of origin?