Mr. John Hennessy:

I will start some of the answers and my colleague, Mr. Judge, may be able to help with others. What happens in the case of Orkambi is that the HSE operates within the scope of its service plan for drug applications for reimbursement brought before it. If we can provide within the scope of our service plan for the applications that present, that is where the decision begins and ends. If an application comes before the HSE that goes beyond our scope and capacity in the service plan, there is a route, as the Deputy said, to escalate the matter to the Department and the Minister.